ingredient sheet

RIAGEV-WS™

RiaGev-WS™ combines three key ingredients, Bioenergy Ribose, Ascorbic Acid, and Nicotinamide , to deliver significant cellular benefits that promote healthy aging. Here's how these components work together to support cellular health:

HECTYL INFORMS YOU

THE ADVANTAGES OF RAGIEV-WS™

NICOTINAMIDE

NAD (nicotinamide) is an essential coenzyme involved in many cellular biochemical reactions, including energy production, metabolic regulation, and DNA repair. With age, NAD levels can decrease, which is associated with a decline in cellular function and accelerated aging. The nicotinamide in RiaGev increases cellular NAD levels, supporting cellular health and function.

BIOENERGY RIBOSE

Ribose is a naturally occurring sugar in the body's cells, essential for the production of adenosine triphosphate (ATP), the primary source of cellular energy. By increasing ribose levels, RiaGev helps support cellular energy production, which is crucial for optimal cell and tissue function.

ASCORBIC ACID

Ascorbic acid is the scientific name for vitamin C, an essential antioxidant for the human body. It helps strengthen the immune system, protect cells from free radical damage, and promote the production of collagen, which is important for skin, bones, and tissues. Ascorbic acid is also crucial for the absorption of iron from food and wound healing.

Nicotinamide

Why is it important to increase NAD?

Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme and metabolite in all human cells. Research indicates that our NAD levels decrease by 50% between our 40s and 60s , negatively impacting the production and longevity of healthy cells.

Decreased NAD levels also make it harder for the body to cope with cellular stress and free radicals.

Increased NAD and healthy mitochondria help slow the aging process, reduce age-related cognitive decline, and prevent cellular damage caused by free radicals.

NAD plays a key role in cellular metabolism and energy production. NAD is vital for mitochondrial health. High levels of NAD are essential for DNA repair and recovery.

NAD, DNA repair and telomeres

There is an important link between NAD+ (nicotinamide adenine dinucleotide) production and telomere repair . This link is primarily mediated by the activity of sirtuins , a family of proteins that play a key role in regulating cell longevity, DNA repair, and telomere protection.

A telomere is a structure located at the end of chromosomes. Chromosomes are the basic units of DNA in a cell, containing all the genetic information necessary for life. Telomeres play a crucial role in protecting these chromosomes and maintaining their integrity.

> GUARENTE, Leonard. Sirtuins in aging and disease. In: Cold Spring Harbor symposia on quantitative biology . Cold Spring Harbor Laboratory Press, 2007. p. 483-488.

< Structure of NAd+

Role of NAD+ in cellular processes

NAD+ is an essential coenzyme involved in several cellular processes, including energy production, cell signaling, and DNA repair. Its role is also crucial for enzymes like sirtuins , which are dependent on NAD+ for their activity.

Sirtuins and telomere repair

Sirtuins , particularly SIRT1 and SIRT6 , are enzymes that require NAD+ for their function. They are involved in several processes that regulate cell lifespan, including the protection and repair of telomeres , the ends of chromosomes that are essential for genomic stability. As cells divide, telomeres gradually shorten, a process linked to cellular aging and disease risk.

SIRT1 : This sirtuin indirectly regulates telomere length by interacting with other proteins responsible for their protection, such as telomerase.

SIRT6 : Plays a direct role in telomere repair by promoting the repair of broken DNA at telomeres and regulating telomerase.

> PROLLA, Tomas A. and DENU, John M. NAD+ deficiency in age-related mitochondrial dysfunction. Cell metabolism , 2014, vol. 19, no. 2, p. 178-180.

> SIRT6 promotes DNA repair under stress by activating PARP1" (Mao Z. et al., 2011)

NAD+ and telomerase

Telomerase is an enzyme that helps lengthen telomeres, thereby counteracting their shortening. Although NAD+ does not directly act on telomerase, the NAD+-dependent activity of sirtuins is involved in the regulation of telomerase and other telomere repair processes.

Bioenergy Ribose

The role of D-ribose

D-ribose is an essential sugar for the synthesis of ATP (adenosine triphosphate), which is the primary energy source for cells. By supporting ATP production, it improves the ability of cells to meet increased energy demands, particularly after physical exertion or cellular stress.

What is ATP?

ATP (adenosine triphosphate) is an energy molecule used by the body's cells to perform almost all of their functions. It can be thought of as a "battery" for cells. Whenever the body needs energy for activities like moving, breathing, or even thinking, ATP is the energy source the cells use.

ATP and aging

With age, ATP production decreases due to the increasing inefficiency of mitochondria. This reduces the ability of cells to repair and function, leading to the deterioration of tissues and organs. Oxidative stress also increases as cells fight free radicals less. As a result, cellular and DNA repair mechanisms are impaired, accelerating aging.

Ascorbic acid

Ascorbic acid, definition

Ascorbic acid , also known as vitamin C , is a powerful antioxidant essential for skin health and collagen production, playing a crucial role in fighting free radicals and maintaining glowing, youthful skin.

> SEE MORE

ADDITIONAL INFORMATION +

RiaGev is the first and only commercially available proprietary compound that uniquely combines Bioenergy Ribose and Vitamin B3 . A third-party pharmacodynamic study has demonstrated that RiaGev enters
directly into the NAD+ biosynthesis pathway and effectively increases NAD+ throughout the body, including muscles and the brain . Simply put, while there are other NR products that are claimed to stimulate NAD production, RiaGev is more effective . It increases NAD levels faster because it enters the pathway directly, requiring fewer steps to produce NAD.

Results will soon be shared for the first human-controlled clinical trial of Bioenergy RiaGev as a healthy aging ingredient. This trial evaluates blood NAD+ levels after use, as well as the presence of NADP, GSH/GSSG, ATP/AMP, circulating cortisol, postprandial blood glucose, and a quality of life assessment.

Preliminary data from this trial show that RiaGev is safe and well tolerated, as well as readily bioavailable.

A patented Hectyl product is:

  • Strict quality control and high purity.

  • Scientific evidence of its effectiveness and safety.

  • Better absorption and better potential performance.

  • Guaranteed consistency between each production batch.

Hectyl, formulas based on scientific expertise and rigorous studies

SEE BIBLIOGRAPHY RiaGev-WS™

> OSUM, Meyrem and SERAKINCI, Nedime. Impact of circadian disruption on health; SIRT1 and Telomeres. DNA repair , 2020, vol. 96, p. 102993.

> MICHISHITA, Eriko, MCCORD, Ronald A., BERBER, Elisabeth, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature , 2008, vol. 452, no. 7186, p. 492-496 .

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2. Berardi, JM, and TN Ziegenfuss. Effects of ribose supplementation on repeated sprint performance in men. J.Strength Cond. Res. 17(1):47–52. (2003).
3. Falk, DJ, KA Heelan, JP Thyfault, and AJ Koch. Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and body composition. J.Strength Cond. Res. 17(4):810–816. (2003).
4. Darin Van Gammeren, MAEd, CSCS, Darin Falk, MAEd and Jose Antonia, PhD, The Effect of Four Weeks of Ribose Supplementation on Body Composition and Exercise Performance in Healthy, Young, Male Recreational Bodybuilders: A Double-Blind Placebo-Controlled Trial, Curr Ther Clin Exp. 63:486-195 (2002).
5. M. Gross, B. Kormann, and N. Zöllner. Klin Wochenschr 69:151-155 (1991).
6. Joanne S. Ingwall, PhD. On the Hypothesis that the Failing Heart Is Energy Starved: Lesson Learned from the Metabolism of ATP and Creatine, Current Hypertension Reports, 8:457-464 (2006).
7. Jacob Teitelbaum, Janelle Jandrain and Ryan McGrew. Treatment of Chronic Fatigue Syndrome and Fibromyalgia with D-Ribose–An Open-label, Multicenter Study, The Open Pain Journal 5: 32-37(2012).
8. JACOB E. TEITELBAUM, MD CLARENCE JOHNSON, MS and JOHN ST. CYR, MD, Ph.D. The Use of D-Ribose in Chronic Fatigue Syndrome and Fibromyalgia: A Pilot Study. THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE Volume 12, Number 9, pp. 857–862 (2006).
9. David J. Perkowski, Susan Wagner, Joseph R. Schneider and JA St. Cyr. A targeted metabolic protocol with D-ribose for off-pump coronary artery bypass procedures: a retrospective analysis. Ther Adv Cardiovasc Dis published online DOI: 10.1177/1753944711412421, (2011).
10. Ragavendra R. Baliga, MD, MBA James B. Young, MD. Editorial
Energizing Diastole, Heart Failure Clin 4 ix–xiii (2008).
11. Dean MacCarter, PhD, Nampalli Vijay, MD, Melinda Washam, MS, Linda Shecterle, PhD, Helen, Sierminski, BA, JA St. Cyr, MD, PhD, Aurora Denver Cardiology Associates, PC, Denver, CO. D-Ribose Aids Advanced Ischemic Heart Failure Patients, International Journal of Cardiology, (2008).
12. Y. Hellsten, EA Richter, B. Kiens and J. Bangsbo. AMP deamination and purine exchange in human skeletal muscle during and after intense exercise, J. Physiol. 520:902-920 (1999).(this information is current as of May 17, 2006)
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Chronological Examination (2003).
14. FALK, Darin J., HEELAN, Kate A., THYFAULT, John P., et al. Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and body composition. The Journal of Strength & Conditioning Research, 2003, vol. 17, no. 4, p. 810-816.
15. BERARDI, John M. and ZIEGENFUSS, Tim N. Effects of ribose supplementation on repeated sprint performance in men. The Journal of Strength & Conditioning Research, 2003, vol. 17, no. 1, p. 47-52.
16. BRAULT, Jeffrey J. and TERJUNG, Ronald L. Purine salvage to adenine nucleotides in different skeletal muscle fiber types. Journal of applied physiology, 2001, vol. 91, no. 1, p. 231-238.
17. HELLSTEN-WESTING, YLVA, NORMAN, BARBARA, BALSOM, PAUL D., et al. Decreased remaining levels of adenine nucleotides in human skeletal muscle after high-intensity training. Journal of Applied Physiology, 1993, vol. 74, no. 5, p. 2523-2528;
18. GROSS, M., KORMANN, B., and ZÖLLNER, N. Ribose administration during exercise: effects on substrates and products of energy metabolism in healthy subjects and a patient with myoadenylate deaminase deficiency. Klinische Wochenschrift, 1991, vol. 69, p. 151-155.
19. WAGNER, DR, GRESSER, U., and ZÖLLNER, N. Effects of oral ribose on muscle metabolism during bicycle ergometer in AMPD-deficient patients. Annals of nutrition and metabolism, 1991, vol. 35, no. 5, p. 297-302.
20. GROSS, M., REITER, S., and ZÖLLNER, N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klinische Wochenschrift, 1989, vol. 67, p. 1205-1213.
21. Bioenergy Life Science, Inc. Online brochure, Increased NAD,ATP and GSH., 2020, https://bioenergylifescience.fr/riagev/
22. Bioenergy Life Science, Inc. Online brochure, Announcing the Next Generation in Skin Health Technology, 2021, https://bioenergylifescience.fr/riagev/
23. American Preclinical Services, Minneapolis, MN; Alex Xue, PhD, Bioenergy Life Science, Inc., Minneapolis, MN. Pharmacodynamics Study Summary of RiaGev™, https://bioenergylifescience.fr/riagev/
24. Bioenergy Life Science, Inc. (accessed 11.07.2024) https://bioenergylifescience.fr/riagev/

Complete Bibliography

Hectyl ingredients

Hectyl formulas, reliable solutions based on patented ingredients and benefits supported by scientific studies.

Hectyl formulas containing RIAGEV-WS™ :

Jouvence_01 - Anti-âge ADN Protect Hectyl

Hectyl

Jouvence_01 - Anti-aging DNA Protect

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