ingredient sheet

PALMITOYLETHANOLAMIDE (PEA)

Palmitoylethanolamide (PEA) is an endogenous molecule, that is to say
Naturally produced by our bodies, particularly in response to inflammatory or painful situations. Discovered in the 1950s, it is often considered a powerful natural anti-inflammatory and analgesic. PEA is part of the fatty acid amide family, active compounds that regulate various biological functions, including those of the immune and nervous systems.

HECTYL INFORMS YOU

THE BENEFITS OF PALMITOYLETHANOLAMIDE (PEA)

NATURAL ANTI-INFLAMMATORY

The PEA
helps reduce inflammation by acting on cell receptors
specific ones such as PPAR-α receptors. It blocks enzymes and molecules
responsible for inflammatory reactions, thus relieving pain
associated with chronic inflammation.

PAIN RELIEF

Known for its analgesic effects, PEA acts directly on cells
nerves to attenuate pain signals. It is often used to treat neuropathic pain, such as that related to sciatica or
chronic conditions.

STRENGTHENING THE IMMUNE SYSTEM

PEA contributes to the regulation of the immune system by modulating excessive immune responses, which may be beneficial in autoimmune or inflammatory diseases.

NEUROPROTECTION

Due to its action on nerve cells, PEA is also being studied for its neuroprotective effects, helping to prevent neuronal damage and promoting the regeneration of damaged nerve tissue.

ADDITIONAL INFORMATION +

Clinically proven effects :

PEA has been the subject of numerous clinical studies demonstrating its effectiveness in managing chronic pain, particularly in conditions such as fibromyalgia, sciatica, and neuropathic pain. It has been used for decades without significant side effects.

Present in food :

Although our bodies produce PEA naturally, small amounts can also be found in certain foods such as eggs and legumes.

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SEE BIBLIOGRAPHY Palmitoylethanolamide

>LAMBERT, Didier M., VANDEVOORDE, Severine, JONSSON, Kent-Olov, et al. The palmitoylethanolamide family: a new class of anti inflammatory agents?. Current medicinal chemistry, 2002, vol. 9, no. 6, p. 663-674.

> ALHOUAYEK, Mireille and MUCCIOLI, Giulio G. Harnessing the anti inflammatory potential of palmitoylethanolamide. Drug Discovery Today , 2014, vol. 19, no. 10, p. 1632-1639. HOAREAU, Laurence, BUYSE, Marion, FESTY, Franck, et al. Anti‐inflammatory effect of palmitoylethanolamide on human adipocytes. Obesity , 2009, vol. 17, no. 3, p. 431-438.

> SCHWEIGER, Vittorio, SCHIEVANO, Carlo, MARTINI, Alvise, et al. Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta Analysis. Nutrients , 2024, vol. 16, no. 11, p. 1653.

> GATTI, Antonio, LAZZARI, Marzia, GIANFELICE, Valentina, et al. Palmitoylethanolamide in the treatment of chronic pain caused by different etiopathogenesis. Pain Medicine , 2012, vol. 13, no. 9, p. 1121-1130.

> SCUTERI, Damiana, GUIDA, Francesca, BOCCELLA, Serena, et al. Effects of palmitoylethanolamide (PEA) on nociceptive, musculoskeletal and neuropathic pain: Systematic review and meta-analysis of clinical evidence. Pharmaceutics , 2022, vol. 14, no. 8, p. 1672.

Complete Bibliography